doi: 10.5732/cjc.011.10432

Will Chinese ovarian cancer patients benefit from knowing the BRCA2 mutation status?

Guo-Yan Liu, Wei Zhang

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin 300052, P. R. China. wzhang@mdanderson.org

[Abstract] In Western countries, the mutation status of the BRCA1 and BRCA2 genes is commonly determined for genetic counseling among members of families with a history of breast or ovarian cancer, especially for women of the Ashkenazi Jewish ethnicity. Recent studies in the Cancer Genome Atlas project have demonstrated that BRCA2 mutation carriers are more responsive to platinum-based chemotherapy among high-grade serous ovarian cancer patients. Thus, in Western countries, the mutation status of BRCA1 and BRCA2 is recognized to have an important value with which to assess cancer risk and therapeutic response. However, very limited studies of BRCA1 and BRCA2 mutations and their implications for counseling and therapeutic prediction have been conducted in China. Therefore, a potentially important genetic test that is technically simple has not benefited Chinese women with an increased risk of breast or ovarian cancer. This article summarizes the current progress in the study of BRCA1/2 mutation in China and recommends an increased effort in applying advances in genetic testing to the clinical management of Chinese patients with ovarian cancer.

Chinese Journal of Cancer 2012, Volume: 31, Issue 1, Page: 1-4

[ PDF Full-text ]
[ Html full-text ](PubMed Central)
[ PubMed ]
[Google Scholar]

Cite this article

Guo-Yan Liu, Wei Zhang. Will Chinese ovarian cancer patients benefit from knowing the BRCA2 mutation status?. Chin J Cancer. 2012, 31(1):1-4. doi:10.5732/cjc.011.10432


Export citations

EndNote