Clinical analysis of 132 cases of cervical adenosquamous carcinoma and cervical adenocarcinoma
Yu-Han Meng , Shuang Li , Ting Hu Ding , Ma Yun-Ping, Lu Hui Wang
Department of Obstetrics and Gynecology, Tumor Molecular Biology Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan, 430030, Hubei, P. R. China. huit71@sohu.com
[Abstract] Background and Objective: The incidence of cervical adenosquamous carcinoma is relatively low. This study was to analyze the clinicopathologic characteristics and prognostic factors of cervical adenosquamous carcinoma. Methods: Clinical data of 44 cervical adenosquamous carcinoma patients and 88 cervical adenocarcinoma patients (control), treated from January 2002 to December 2007, were analyzed using Chi-square test, Kaplan-Meier method, log-rank test, and Cox regression model. Results: The proportion of large tumors (maximum diameter >4 cm) and that of poorly-differentiated tumors was significantly higher in the cervical adenosquamous carcinoma group than in the cervical adenocarcinoma group (47.7% vs. 28.4%, 56.8% vs. 30.7%, respectively, P<0.05). Univariate analysis showed that tumor size (P=0.011), FIGO stage (P=0.013), depth of stromal invasion (P=0.05), and lymph node metastasis (P=0.017) were correlated with prognosis, and multivariate analysis showed that FIGO stage and lymph node metastasis were independent prognostic factors. There was no significant difference of 2-year overall or disease-free survival rates between the two groups (P>0.05). Conclusions: Cervical adenosquamous carcinoma is characterized by large tumor size and poor differentiation. FIGO stage and lymph node metastasis are significant prognostic factors. There is no difference in prognosis between cervical adenosquamous carcinoma and cervical adenocarcinoma.
Chinese Journal of Cancer 2010, Volume: 29, Issue 1, Page: 15-
SHARE THIS ARTICLE
Comments:
